Endocrine Abstracts

Introduction: Adrenocortical carcinomas are rare aggressive tumors. 36 % of patients with ACC have distant metastasis on presentation. Although lung metastasis are commonly seen in metastatic Adrenocortical carcinoma, cannonball pulmonary metastasis which are solid and well circumscribed parenchymal masses of variable size are rare and typically seen in Renal cell carcinoma and also in other cancers such as bone sarcomas. We report a case of functional Adrenocortical cancer wi...

We would like to present this fascinating case in the forthcoming BES meeting as an oral or poster presentation.A 65-year-old retired teacher was found on routine check up by her GP to be severely hypothyroid biochemically (TSH 70.89 mU/l (0.4–5.0) and fT4 7.5 pmol/l (12.0–23.0)).There were no symptoms suggestive of hypothyroidism whatsoever. She was full of energy, not gaining weight, not cold intolerant, not constipated...

Background: Hypercalcaemia in endocrine patients often poses diagnostic challenge, with hyperparathyroidism and familial hypocalciuric-hypercalcaemia(FHH) being common differentials. This case-report presents unique and complex aetiology, underscoring need for comprehensive evaluation.Case-Description: We present case of 57-year-old Caucasian-woman referred to our clinic with persistently elevated calcium and parathyroid...

Introduction: Insulinoma is a pancreatic tumor that induces hypoglycemia due to over secretion of Insulin. Common symptoms include headache, diplopia, palpitations, blurred vision and unconsciousness. Approximately 90% of insulinomas are benign. Insulinoma is characterized by the Whipple triad, which includes symptoms of hypoglycemia, concomitant plasma glucose of less than 50 mg/dl, and reversal of symptoms after correction of hypoglycemia.Case presenta...

A 68-year-old male presented with fatigue and acute onset polyuria and polydipsia. There was no history of headaches, visual symptoms, previous cranial radiations, chemotherapy or CNS infections. Investigations revealed normal fasting glucose, urea, creatinine, liver functions and electrolytes including calcium. Further workup including pituitary profile, paired osmolalities and water deprivation test confirmed hypopituitarism and cranial diabetes insipidus (Table 1). The unde...

Case history: 81-year-old female patient admitted for fracture neck of femur was referred to endocrinology for high T4. Clinically she was euthyroid with mild thyroid eye disease.PMH: Atrial fibrillation Post CABG 30.09.15, Hypothyroidism since 1983 (started on Eltroxin by GP for weight gain and tiredness though patient never had biochemical evidence of hypothyroidism), OA of spine 2007, T2DM, Asthma.Drug history: Amioda...

Case history: 62 Year old male known to have inflammatory bowel disease, ischemic cardiomyopathy, ICD implant for sustained ventricular tachycardia was referred to endocrine clinic by the GP for thyrotoxicosis which was found on lab workup for worsening diarrhoea and tiredness.Drug historyAmiodarone 200 mg od since 2012, Bisoprolol, Eplerenone, Atorvastain and Pentasa.Investigations: FT4 48.6 pmol/l (6.5&#150...

BackgroundRadioiodine therapy (RAI) is an effective treatment for hyperthyroidism, being used with increasing frequency. There is no consensus as to the correct use of radioiodineThe aim is to compare our practice to the standards recommended by the working group of the Royal College of Physicians and Society for Endocrinology and to measure the outcome at one year of using a fixed dose of RAI (555 Mbq) .Meth...

A 76yr old lady presented to A&E with 'collapse and fall', 2 days following self-discharge for the same complaint. She had a medical history of type 2 diabetes on Gliclazide 80 mg o.d. and osteoarthritis of the spine.She was noted to be tanned with pigmented palmar creases and had marked postural hypotension. Biochemistry showed serum sodium 124 millimols per litre, potassium 4.6 millimols per litre and cortisol 43 nanmols per litre. A short synacthe...

Case history: A 25 year old primigravid woman was referred through to the Joint Antenatal clinic with a 15-year history of Diabetes Mellitus Type 2 treated with metformin. Her past medical history included polycystic ovarian syndrome, (causing significant hirsutism and amenorrhoea), non-alcoholic fatty liver disease, dyslipidaemia and hypertension (previously investigated for secondary causes). Her HbA1c was well controlled at 30 mmol/mol, and her Metformin had been discontinu...